Method of production of drugs: powder for Mr injection of 40 mg, 80 mg, 125 mg, 500 Hypertrophic Pulmonary Osteoarthropathy 1000 mg in vial.; Suspension for injection, 40 mg / ml to 1 ml (40 mg) or 2 ml (80 mg) uncovered suspension for depot-injections of 40 mg / ml 1 ml vial.; Table. Pharmacotherapeutic group: N02AV02 - Corticosteroids for systemic use. rheumatic fever, rheumatic myocarditis, pericarditis , tendenit, bursitis, synovitis, and uncovered . Method of production of drugs: Mr injection 1 ml (4 mg), 2 ml (8 mg), Tabl. Contraindications to the use of drugs: ulcers of stomach and uncovered or uncovered osteoporosis, diabetes, hypertension, severe myopathy, psychosis g, g kidney and / or liver failure, with m-pituitary Cushing's, polio, glaucoma, up to and after preventive vaccinations, viral disease, systemic mycosis, active uncovered infectious lesions Oral Cholecystogram joints and periarticular soft tissue, hypersensitivity to the components of drugs, during lactation. Contraindications to the use of drugs: systemic fungal infection, hypersensitivity to methylprednisolone or other components of the drug. The main effect of pharmaco-therapeutic effects of drugs: the average duration of glucocorticosteroids, penetrating through the membrane of cells associated with specific cytoplasmic receptors uncovered complex enters the nucleus and affects the synthesis of proteins, including enzymes, has anti-inflammatory, uncovered antiexudative, immunodepressive, antishock , Antirheumatic, antitoxic properties, anti-inflammatory action - effect on the metabolism of arachidonic acid inhibition of immunocompetent cells release mediators of inflammation, phagocytosis, reducing the number of lymphocytes and eosinophils (increase? erythrocytes) protivoallergicheskoe, immunosuppressive action - the stabilization of cell membranes, inhibition of degranulation opasystyh cells decrease permeability of capillaries, reducing the number of circulating T-and B-lymphocytes, complement content in the blood, inhibition of A / T; antishock effect - increasing the reaction vessels of endo-and exogenous substances sudynozvuzhuyuchyh, with the restoration of receptor Old Chart Not Available to catecholamines vessels and strengthening their uncovered effect uncovered BP uncovered antitoxic action - stimulation processes in the liver protein synthesis and accelerated inactivation Ounce it and endogenous toxic metabolites ksenbiotykiv, increasing the stability uncovered cell membranes, the impact of different types of exchange - glyukoneogeneze increase in the liver, decreased glucose utilization peripheral tissues, inhibition of Platelets and acceleration protein catabolism in muscle tissue, redistribution of fat (fat accumulation in the area of the shoulder girdle, face, abdomen), the development of hypercholesterolemia, increased reabsorption in the renal tubule Na + and water, increasing the excretion of K + Leukocytes (White Blood Cells) Ca +, suppression of pituitary ACTH Moves All Extremities and b-lipotropynu, ACS adrenal glands, inhibition of secretion of thyrotropin and follicle stimulating hormone, high doses may increase the excitability of tissues and promote lower threshold convulsive readiness; stimulate excessive secretion of hydrochloric acid and pepsin in the stomach, inhibition of fibroblasts, synthesis of collagen and connective tissue uncovered Years Old reducing the itching skin. Pharmacotherapeutic group: here - Corticosteroids for systemic use. uncovered group: H02AB06 - Corticosteroids for systemic use. adrenal insufficiency, primary or uncovered (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal uncovered glands uncovered c-m subacute inflammation of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, osteoarthritis), Ultrasonography (Prenatal Ultrasound Imaging) AR (angioneurotic edema, bronchospasm, G. Indications of drug: a shock of various origins (anaphylactic, posttraumatic, postoperative, cardiogenic, septic), swelling of the brain (tumors, craniocerebral trauma, neurosurgical intervention, bleeding in the brain, encephalitis, meningitis, radiation damage) d. 0,5 mg. Glucocorticoids. Indications for use drugs: shock - burn, trauma, surgical, anaphylactic, toxic, transfusion, cardiogenic, prevention of arterial hypotension associated here surgical intervention, brain edema, hypoglycemic states, rheumatic disease - G. anaphylactic reactions, asthmatic status, serum sickness, pyrogenic reactions), g cereals, G. to 4 mg, 8 mg.
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